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July 1, 1943Journal of Clinical InvestigationOpen Access

A Study of the Volume of the Blood in Congestive Heart Failure. Relation to Other Measurements in Fifteen Patients

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Key result

In patients with congestive heart failure, there was no significant correlation between venous pressure and blood volume (correlation coefficient -0.418).

Population

15 patients with severe congestive heart failure, dyspneic or orthopneic, mostly with pitting edema and…

Design

Cross-sectional

Authors

GMGeorge R. MeneelyLouisiana State University in ShreveportNKNolan L. KaltreiderStrong Memorial Hospital

Discussion

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Implication

Questions venous pressure as blood volume surrogate in heart failure; cross-sectional data leave open mechanisms and require prospective confirmation.

Study Design

Type

Observational (n=15)

Structured PICO

P
Population
15 patients with congestive heart failure.
O
Outcome
Correlation between blood volume (and its fractions) and other cardiovascular measurements including venous pressure, circulation time, and capillary unsaturation.surrogate

Main Result

Effect estimate: r = -0.418

p-value: p=not significant

In patients with severe congestive heart failure, blood volume is substantially increased but does not correlate simply with venous pressure or circulation time.

Limitations

  • Very limited series of patients (n=15)
  • Selection only of severely congested cardiacs
  • Impossibility of evaluation of right versus left heart failure from the data obtained

Cite This Study

Meneely et al. (1943) conducted an observational in Congestive heart failure (n=15). Physiological measurements (venous pressure, blood volume, circulation time) was evaluated on Correlation between venous pressure and blood volume (r = -0.418, p=not significant). In patients with congestive heart failure, there was no significant correlation between venous pressure and blood volume (correlation coefficient -0.418).

synapsesocial.com/papers/6a9d71f2a07850bc91a4c599https://doi.org/10.1172/jci101422
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