Key result
Venous congestion of one arm for three hours reduced forearm venous volume by 22%, resting forearm blood flow by 49%, and peak reactive hyperemia blood flow by 25%.
Why the study?
Does short-term venous congestion reduce forearm venous volume and reactive hyperemia blood flow in normal human volunteers?
Does short-term venous congestion reduce forearm venous volume and reactive hyperemia blood flow in normal human volunteers?
Short-term venous congestion alone can induce reductions in limb venous volume and reactive hyperemia blood flow similar to those seen in congestive heart failure.
Answers are grounded in this paper and cite their sources.
Venous congestion may contribute to HF-related vascular changes; hypothesis-generating for decongestion as a modifiable target.
Congestive heart failure is associated with a reduction in limb venous volume at an effective venous pressure of 30 mm Hg (VV[30]). Further, an attenuated arteriolar dilation in response to a metabolic stimulus has been demonstrated. It was the purpose of this study to determine to what extent the chronic elevation in venous pressure seen in heart failure might explain these abnormalities of the limb circulation. Ten normal human volunteers were subjected to venous congestion of one arm for three hours at 70 mm Hg. A mercury-in-rubber strain gauge plethysmograph was used to measure forearm VV [30] and forearm blood flow at rest after release of five minutes of arterial occlusion (the reactive hyperemia response). Congestion reduced VV [30] 22%, resting forearm blood flow 49% and peak reactive hyperemia blood flow 25%. Thus, chronic venous congestion per se may significantly reduce limb venous volume as well as resting and reactive hyperemia blood flow.
No takes yet. Share an insight, caveat, or question.
Zelis et al. (1978) studied Healthy volunteers (n=10). Venous congestion vs. Baseline was evaluated on Forearm venous volume at 30 mm Hg (VV[30]), resting forearm blood flow, and peak reactive hyperemia blood flow (22% reduction in VV[30], 49% reduction in resting blood flow, 25% reduction in peak reactive hyperemia blood flow). Venous congestion of one arm for three hours reduced forearm venous volume by 22%, resting forearm blood flow by 49%, and peak reactive hyperemia blood flow by 25%.
Synapse has enriched 10 related papers. Consider them for comparative context: