Key result
Age <10 years at the time of aortic valve repair with VSD closure did not significantly affect freedom from moderate or greater residual aortic regurgitation at 10 years compared to age ≥10 years (55% vs 47.4%; p=0.084).
Why the study?
To evaluate early and late clinical outcomes of aortic valve repair in patients with ventricular septal defect and analyze whether age predicts repair failure.
Does age at surgery affect early and late clinical outcomes in patients undergoing aortic valve repair with concomitant ventricular septal defect closure?
Cohort (n=159)
Does age at surgery affect early and late clinical outcomes in patients undergoing aortic valve repair with concomitant ventricular septal defect closure?
Aortic valve repair with concomitant ventricular septal defect closure provides satisfactory long-term survival and freedom from reintervention across pediatric and older age groups.
Answers are grounded in this paper and cite their sources.
Supports repair across ages without excess regurgitation risk; leaves open prospective confirmation of uniform outcomes.
BACKGROUND: The aim of the study is to evaluate early and late clinical outcomes of patients undergoing the aortic valve repair in patients associated with ventricular septal defect and to analyze whether age is a risk factor predicting repair failure. METHODS: All patients who were underwent aortic valve repair with concomitant ventricular septal defect closure from 2006 to 2018 were included and divided into two groups: less than 10 years (Group 1) and more than or equal to 10 years (Group 2). RESULTS: About 159 patients were included (Group 1 = 92; Group 2 = 67). Overall median age was 8 years, 70% were males. The most common ventricular septal defect was perimembranous in both groups. Two patients in Group 2 had to undergo aortic valve replacement subsequently which resulted in early mortality. Univariable analysis showed prolonged ventilation (p < .001), postoperative intensive care unit stay (p = .019) as significant factors for early mortality. Estimated survival was 97.6% ± 2.4 at the end of 5 years and 10 years in Group 1 and 93.6% ± 3.6 in Group 2. Freedom from residual aortic regurgitation more than or equal to moderate at 5 years and 10 years was 85.6% ± 4.9 and 55% ± 13.8 in Group 1 and 76.9% ± 6.7 and 47.4% ± 12.2 in Group 2, however, it was not significant (p = . .084). CONCLUSION: The aortic valve repair in patients with ventricular septal defect provides satisfactory early and late results in terms of mortality and need for reintervention in all age groups.
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Kaskar et al. (2021) conducted a cohort in Ventricular septal defect requiring aortic valve repair (n=159). Age < 10 years vs. Age ≥ 10 years was evaluated on Freedom from residual aortic regurgitation more than or equal to moderate at 10 years (p=0.084). Age <10 years at the time of aortic valve repair with VSD closure did not significantly affect freedom from moderate or greater residual aortic regurgitation at 10 years compared to age ≥10 years (55% vs 47.4%; p=0.084).
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