Key result
More than half of patients presenting with acute lymphocytic myocarditis and LVEF <50% showed persistent LV dysfunction at 1 year, with poor lymphocytic infiltrate emerging as a strong independent predictor (OR 12.40).
Why the study?
Persistent left ventricular systolic dysfunction in patients with acute lymphocytic myocarditis is widely unexplored.
Cohort (n=48)
Yes
Odds Ratio: 12.4 (95% CI 1.23–124.97)
Absolute Event Rate: 86.7% vs 42.4%
p-value: p=0.010
More than half of patients with acute lymphocytic myocarditis and reduced LVEF at admission exhibit persistent LV dysfunction at 1 year, which is strongly predicted by larger baseline LV size, non-fulminant presentation, and poor lymphocytic infiltrate.
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May refine prognosis in lymphocytic myocarditis; leaves open whether infiltrate guides therapy without randomized data.
Merlo et al. (2019) conducted a cohort in Acute lymphocytic myocarditis with reduced LVEF (n=48). Poor lymphocytic infiltrate vs. Moderate to plentiful lymphocytic infiltrate was evaluated on Persistent LV dysfunction (LVEF <50% at 1-year) (OR 12.40, 95% CI 1.23-124.97, p=0.010). More than half of patients presenting with acute lymphocytic myocarditis and LVEF <50% showed persistent LV dysfunction at 1 year, with poor lymphocytic infiltrate emerging as a strong independent predictor (OR 12.40).
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