What is the clinical evidence from this study?

Study design: Other. Intervention: LACI and heparin vs. LACI or heparin alone. Primary outcome: Coagulation time (APTT and PT).

January 15, 1992Blood

Lipoprotein-associated coagulation inhibitor (LACI) is a cofactor for heparin: synergistic anticoagulant action between LACI and sulfated polysaccharides

View Full Paper

Ask AI

Bookmark

Key result

LACI serves as a cofactor for heparin, greatly enhancing the inhibition of tissue factor-induced coagulation, and acts synergistically with sulfated polysaccharides in whole plasma.

Population

Normal plasma and LACI-depleted plasma

Comparison

Heparin, purified recombinant LACI, and various… vs LACI-depleted plasma without heparin/LACI, or…

Design

Preclinical

Authors

TWTC WunMonsanto (United States)

Discussion

Member takes

Implication

LACI-heparin synergy in animal plasma merits human investigation; leaves open clinical translation from Level 5 data.

Structured PICO

Population

Normal plasma and LACI-depleted plasma

Intervention

Heparin, purified recombinant LACI, and various sulfated polysaccharides (e.g., low molecular weight heparin, pentosan polysulfate, dermatan sulfate, dextran sulfate, heparan sulfate)

Comparator

LACI-depleted plasma without heparin/LACI, or normal plasma without heparin

Outcome

Coagulation time measured by activated partial thromboplastin time (APTT) and modified prothrombin time (PT)surrogate

LACI acts as a cofactor for heparin and other sulfated polysaccharides, synergistically enhancing the inhibition of tissue factor-induced coagulation.

Cite This Study

TC Wun (1992) studied this question. LACI and heparin vs. LACI or heparin alone was evaluated on Coagulation time (APTT and PT). LACI serves as a cofactor for heparin, greatly enhancing the inhibition of tissue factor-induced coagulation, and acts synergistically with sulfated polysaccharides in whole plasma.

synapsesocial.com/papers/6a9d99e9a07850bc91a4d671 https://doi.org/10.1182/blood.v79.2.430.bloodjournal792430

View Full Paper

Ask AI

Bookmark

Lipoprotein-associated coagulation inhibitor (LACI) is a cofactor for heparin: synergistic anticoagulant action between LACI and sulfated polysaccharides

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Lipoprotein-associated coagulation inhibitor (LACI) is a cofactor for heparin: synergistic anticoagulant action between LACI and sulfated polysaccharides

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider