Key result
Heparin-releasable lipoprotein-associated coagulation inhibitor was purified 185,000-fold with a 33% yield and shown to be structurally different from lipoprotein LACI.
Population
Post-heparin plasma for in vitro purification and a rabbit model for in vivo clearance
Comparison
Purification of heparin-releasable… vs I125-labeled HepG2 LACI and lipoprotein LACI
Design
Preclinical
Authors
Loading...
Animal data distinguish heparin-releasable LACI; leaves open its endothelial role and human relevance.
Heparin-releasable LACI is structurally distinct from lipoprotein LACI and has a slower clearance rate in vivo, suggesting association with vascular endothelium.
Novotny et al. (1991) studied this question. Heparin-releasable LACI (HRL) purification vs. Lipoprotein LACI / HepG2 LACI was evaluated on Purification yield and structural properties. Heparin-releasable lipoprotein-associated coagulation inhibitor was purified 185,000-fold with a 33% yield and shown to be structurally different from lipoprotein LACI.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: