Key result
Higher overall Life's Simple 7 scores were significantly associated with lower odds of mild cognitive impairment in community-dwelling older adults (OR 0.805; 95% CI 0.690-0.939).
Why the study?
Although components of Life's Simple 7 are reported risk factors for dementia, few studies have investigated the association between the Life's Simple 7 metric and mild cognitive impairment.
Does a higher Life's Simple 7 score reduce the odds of mild cognitive impairment in community-dwelling older adults?
Cross-Sectional (n=297)
No
Does a higher Life's Simple 7 score reduce the odds of mild cognitive impairment in community-dwelling older adults?
Odds Ratio: 0.805 (95% CI 0.69–0.939)
Higher Life's Simple 7 scores are associated with lower odds of mild cognitive impairment in older adults, suggesting cardiovascular health metrics may help guide dementia prevention.
May support cognitive risk assessment in older adults; hypothesis-generating for trials testing Life's Simple 7 interventions on MCI.
Background: Life's Simple 7 (LS7), a metric composed of seven intervenable cardiovascular risk factors, is initiated by the American Heart Association to improve cardiovascular health. The components of LS7 have been reported as risk factors for dementia. However, few studies investigated the association between LS7 metric and mild cognitive impairment (MCI). Methods: The study was carried out in a primary care facility between 8 June and 10 July 2022. A total of 297 community-dwelling residents aged 65 years or older were recruited. Sociodemographic, comorbidity, and lifestyle characteristics were collected through the questionnaires, and biological parameters were obtained from blood sample examinations. Logistic regression was used to analyze the association between LS7 scores (overall, behavioral, and biological) and individual components with MCI, adjusting sex, age, education, and cardiovascular disease (CVD). Results: = 102) had a lower education level and a higher proportion of hypertension. Multivariate logistic regression analysis, adjusting sex, age, education, and CVD demonstrated a significant association between MCI and overall LS7 score [odd ratio = 0.805, 95% confidence interval (0.690, 0.939)] and biological score [odd ratio = 0.762, 95% confidence interval (0.602, 0.965)]. Conclusion: Life's Simple 7 was associated with MCI in community-dwelling older adults, indicating that LS7 could be used as guidance in the prevention of dementia in the community.
No takes yet. Share an insight, caveat, or question.
Yang et al. (2023) conducted a cross-sectional in Mild cognitive impairment (MCI) (n=297). Life's Simple 7 (LS7) score was evaluated on Mild cognitive impairment (MCI) (OR 0.805, 95% CI 0.690-0.939). Higher overall Life's Simple 7 scores were significantly associated with lower odds of mild cognitive impairment in community-dwelling older adults (OR 0.805; 95% CI 0.690-0.939).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: