Key result
The hepatitis C virus internal ribosome entry site contains a series of discontinuous domains that together form the largest ribosome binding site discovered to date.
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May offer a novel HCV antiviral target; leaves open whether this architecture is unique or shared among viruses.
Lytle et al. (2001) studied Hepatitis C Virus (in vitro). HCV IRES RNA vs. beta-globin mRNA was evaluated on Ribosome binding site characterization. The hepatitis C virus internal ribosome entry site contains a series of discontinuous domains that together form the largest ribosome binding site discovered to date.
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