Key result
Propranolol infusion significantly decreased the extravascular norepinephrine release rate from 15.5 to 9.2 nmol/min/m2 (P=0.0002) in healthy subjects.
Why the study?
Does propranolol infusion alter extravascular norepinephrine release in healthy subjects?
Population
9 healthy subjects
Comparison
Propranolol (PRP) infusion vs Saline infusion (sequential)
Design
Other
Authors
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May indicate additional sympathetic suppression by nonselective beta-blockers; hypothesis-generating and requires confirmation in patients.
Does propranolol infusion alter extravascular norepinephrine release in healthy subjects?
Absolute Event Rate: 9.2% vs 15.5%
p-value: p=0.0002
Propranolol decreases extravascular norepinephrine release in humans, indicating that suppression of sympathetic nervous system activity may be an additional mechanism of action for nonselective beta-blockers.
Rosen et al. (1990) studied Healthy (n=9). Propranolol (PRP) vs. Saline was evaluated on Extravascular norepinephrine (NE) release rate (p=0.0002). Propranolol infusion significantly decreased the extravascular norepinephrine release rate from 15.5 to 9.2 nmol/min/m2 (P=0.0002) in healthy subjects.
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