Key result
BC3H1 myocytes express both vascular smooth muscle and sarcomeric skeletal muscle alpha-actin isoforms during differentiation, with sarcomeric alpha-actin induced late after serum deprivation.
Population
BC3H1 smooth muscle-like cell line
Design
Preclinical
Authors
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Supports BC3H1 as an in vitro model for muscle differentiation; leaves open translation to human cardiovascular disease.
The BC3H1 cell line exhibits dual, sequential expression of smooth muscle and sarcomeric skeletal muscle alpha-actins during differentiation, providing a useful model for studying muscle gene regulation.
Strauch et al. (1989) studied BC3H1 cell differentiation. Serum deprivation was evaluated on Expression of smooth muscle and sarcomeric alpha-actin isoforms. BC3H1 myocytes express both vascular smooth muscle and sarcomeric skeletal muscle alpha-actin isoforms during differentiation, with sarcomeric alpha-actin induced late after serum deprivation.
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