Key result
A high resting heart rate (≥80 bpm) was associated with increased odds of osteoporosis compared to a lower heart rate in older women with hypertension (OR 1.7; 95% CI 1.2-2.3).
Why the study?
Is high resting heart rate associated with lower bone mineral density in older women with hypertension?
Cohort (n=981)
Is high resting heart rate associated with lower bone mineral density in older women with hypertension?
Odds Ratio: 1.7 (95% CI 1.2–2.3)
High resting heart rate is independently associated with lower bone mineral density and higher osteoporosis risk in older hypertensive women.
May identify older hypertensive women for bone density screening; hypothesis-generating and should not change practice without prospective data.
OBJECTIVES: To determine whether high heart rate is associated with low bone mineral density (BMD) in older women with hypertension. DESIGN: Retrospective cohort study. SETTING: Population-based study conducted in Korea (Korea National Health and Nutritional Examination Survey 2009-10). PARTICIPANTS: Postmenopausal women aged 60 and older with hypertension (N=981) divided into 2 groups according to resting heart rate, with a cut-off value of 80 bpm, which has been found to be associated with osteoporosis. MEASUREMENTS: BMD profiles and clinical and laboratory data were collected. Osteoporosis was defined as a T-score of -2.5 or less, according to World Health Organization criteria. RESULTS: BMD was significantly lower in participants with a high heart rate, even after adjustment for age, diabetes mellitus, white blood cell count, and fasting glucose and triglyceride levels. The prevalence of osteoporosis was also significantly higher in those participants. In multivariate logistic regression analysis, the group with high heart rate was 1.7 times as likely (95% confidence interval=1.2-2.3) to have osteoporosis as those with a lower heart rate, independent of age, body mass index, comorbidities, and laboratory findings. CONCLUSION: High heart rate is independently associated with lower BMD in older women with hypertension; proactive surveillance of BMD could be helpful when managing older women with hypertension and a high heart rate.
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Jung et al. (2018) conducted a cohort in hypertension (n=981). High resting heart rate (≥80 bpm) vs. Lower resting heart rate (<80 bpm) was evaluated on Osteoporosis (T-score ≤ -2.5) (OR 1.7, 95% CI 1.2-2.3). A high resting heart rate (≥80 bpm) was associated with increased odds of osteoporosis compared to a lower heart rate in older women with hypertension (OR 1.7; 95% CI 1.2-2.3).
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