Key result
Mathematical modelling demonstrates that epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis based on current parameter estimates.
Population
Bovine epithelial tissues infected with Foot-and-Mouth Disease Virus modeled using partial differential…
Design
Preclinical
Follow-up
approximately 48 hours (model timescale)
Authors
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Questions epithelial thickness in FMDV lesion models; leaves open receptor distribution and replication kinetics for targeted study.
Mathematical modeling suggests that differences in receptor distribution or viral replication, rather than epithelial thickness, may drive the tissue-specific development of FMDV-induced lesions.
Giorgakoudi et al. (2015) studied Foot-and-mouth disease (FMD). Mathematical modelling of FMDV infection was evaluated on Cell lysis (cellular space fraction). Mathematical modelling demonstrates that epithelial tissue thickness and cell layer structure are unlikely to be determinants of FMDV-induced cell lysis based on current parameter estimates.
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