Key result
Levosimendan and prostaglandin E1 both improved haemodynamics and reduced BNP at 24 and 48 hours in decompensated heart failure, though the neurohormonal benefit was not sustained at 1 week for levosimendan.
Why the study?
Does levosimendan improve haemodynamic and neurohormonal parameters in patients with decompensated chronic heart failure, and for how long?
Population
Patients with decompensated chronic heart failure
Design
Editorial
Authors
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This letter highlights the prolonged haemodynamic and neurohormonal effects of levosimendan, suggesting a potential rationale for scheduling serial administrations every 2-3 weeks in advanced heart failure.
Does levosimendan improve haemodynamic and neurohormonal parameters in patients with decompensated chronic heart failure, and for how long?
This letter highlights the prolonged haemodynamic and neurohormonal effects of levosimendan, suggesting a potential rationale for scheduling serial administrations every 2-3 weeks in advanced heart failure.
Parissis et al. (2006) conducted a letter in Decompensated chronic heart failure. Levosimendan vs. Prostaglandin E1 (PGE1) was evaluated on Haemodynamic parameters and BNP. Levosimendan and prostaglandin E1 both improved haemodynamics and reduced BNP at 24 and 48 hours in decompensated heart failure, though the neurohormonal benefit was not sustained at 1 week for levosimendan.