Key result
The pathological diagnosis of myocarditis relies on histopathological criteria, and understanding the role of enteroviruses is fostering new perspectives for therapeutic interventions.
Understanding the histopathological criteria and disease-specific sensitivity of endomyocardial biopsy, alongside the role of enteroviruses, enhances the clinical utility of diagnosing and potentially treating myocarditis.
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Histopathological criteria remain central to myocarditis diagnosis; leaves open enterovirus-targeted therapies as hypothesis-generating.
The pathological diagnosis of myocarditis rests on well-described histopathological criteria. Appreciation for the disease-specific sensitivity of the endomyocardial biopsy, as well as the phenotypical and functional nature of inflammatory infiltrates, will enhance the clinical utility of the biopsy technique. New information regarding the role of enteroviruses in immunological sensitization and the study of enteroviruses in murine models and human patients are fostering new perspectives and routes of investigation of appropriate therapeutic interventions for myocarditis.
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McManus et al. (1991) conducted a review in Myocarditis. The pathological diagnosis of myocarditis relies on histopathological criteria, and understanding the role of enteroviruses is fostering new perspectives for therapeutic interventions.
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