Key result
Paracetamol and ibuprofen demonstrated similar overall closure rates (76.25% vs 75%) for the treatment of hemodynamically significant patent ductus arteriosus in preterm infants.
Why the study?
Paracetamol can be used for the pharmacological closure of hsPDA in preterm infants, but more research was required regarding its efficacy and safety compared to standard therapy.
Does paracetamol improve ductal closure rate compared to ibuprofen in preterm infants with hemodynamically significant patent ductus arteriosus?
Population
100 consecutive preterm infants with hsPDA
Comparison
Paracetamol vs ibuprofen
Design
Observational study
Authors
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Supports similar efficacy of paracetamol and ibuprofen for PDA closure in preterm infants; leaves open need for RCTs before changing practice.
Observational (n=100)
No
Does paracetamol improve ductal closure rate compared to ibuprofen in preterm infants with hemodynamically significant patent ductus arteriosus?
Absolute Event Rate: 76.25% vs 75%
p-value: p=1.0931
Paracetamol is as effective as ibuprofen for the pharmacological closure of hemodynamically significant patent ductus arteriosus in preterm infants, and may be preferred in patients with comorbidities or low platelet counts.
Swathi et al. (2023) conducted an observational in Hemodynamically significant patent ductus arteriosus (hsPDA) (n=100). Paracetamol vs. Ibuprofen was evaluated on Overall rate of ductal closure (p=1.0931). Paracetamol and ibuprofen demonstrated similar overall closure rates (76.25% vs 75%) for the treatment of hemodynamically significant patent ductus arteriosus in preterm infants.
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