Key result
Activated clotting time (ACT) screening prior to catheter-based procedures demonstrated 91% sensitivity, 27% specificity, and 95% positive predictive value for normal coagulation profiles.
Why the study?
Does activated clotting time (ACT) accurately screen for coagulation abnormalities compared to standard coagulation profiles prior to catheter-based cardiovascular procedures?
Observational (n=963)
Does activated clotting time (ACT) accurately screen for coagulation abnormalities compared to standard coagulation profiles prior to catheter-based cardiovascular procedures?
ACT is an acceptable, rapid screening test with high positive predictive value for normal coagulation, though its low specificity necessitates standard coagulation studies in high-risk patients or those with ACT > 150 seconds.
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ACT may support rapid pre-procedure screening; leaves open replacement of standard tests given low specificity in cross-sectional data.
Siskin et al. (2001) conducted an observational in Patients undergoing catheter-based cardiovascular procedures (n=963). Activated clotting time (ACT) vs. Standard coagulation profile was evaluated on Normal coagulation profile. Activated clotting time (ACT) screening prior to catheter-based procedures demonstrated 91% sensitivity, 27% specificity, and 95% positive predictive value for normal coagulation profiles.
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