Key result
In guinea pig cardiomyocytes with blocked phosphorylation pathways, Gs activation increased calcium current by approximately 50%, indicating fast, membrane-delimited Gs modulation.
Population
guinea pig cardiomyocytes
Design
Preclinical
Authors
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Demonstrates that fast, membrane-delimited Gs modulation participates in the physiological regulation of cardiac calcium current independently of phosphorylation pathways.
Demonstrates that fast, membrane-delimited Gs modulation participates in the physiological regulation of cardiac calcium current independently of phosphorylation pathways.
Pelzer et al. (1990) studied this question. Gs protein activation (beta-receptor activation, intracellular activation, or application of preactivated Gs) vs. Blocked phosphorylation pathways was evaluated on Calcium current (ICa). In guinea pig cardiomyocytes with blocked phosphorylation pathways, Gs activation increased calcium current by approximately 50%, indicating fast, membrane-delimited Gs modulation.
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