Key result
Residual renal function was negatively correlated with heart rate variability parameters including SDNN (r = -0.284, p = 0.017), TP (r = -0.247, p = 0.039), and HF (r = -0.238, p = 0.047).
Why the study?
Is residual renal function associated with heart rate variability in peritoneal dialysis patients?
Cross-Sectional (n=71)
Is residual renal function associated with heart rate variability in peritoneal dialysis patients?
In peritoneal dialysis patients, residual renal function status is independently associated with heart rate variability, with declining RRF linked to sympathetic activation.
May signal autonomic imbalance warranting monitoring in peritoneal dialysis; leaves open causal effects and interventional trials.
BACKGROUND: The relationship between heart rate variability (HRV) and residual renal function (RRF) has not been elucidated previously. METHODS: In this cross-sectional study, HRV was evaluated in 71 peritoneal dialysis patients. Patients were divided into RRF decline group, RRF stable group and anuric group. RESULTS: RRF was negatively correlated with SDNN (r = -0.284, p = 0.017), TP (r = -0.247, p = 0.039), and HF (r = -0.238, p = 0.047). Significant sympathetic nerve activation was found in the RRF decline group (significantly lower SDNN, SDSD, RMSSD, pNN50, LF, HF, TP and higher LF/HF ratio) as compared to the RRF stable and anuric groups. Besides, significantly parasympathetic activation was found in the anuric group (the lowest LF/HF ratio as compared to the other groups (both p < 0.05). Multivariate stepwise regression analysis showed that the status of RRF was an independent factor associated with HRV parameters. CONCLUSION: This study showed autonomic nervous function in peritoneal dialysis patients was associated with a different status of RRF.
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Tang et al. (2012) conducted a cross-sectional in peritoneal dialysis (n=71). Residual renal function (RRF) status vs. RRF stable and anuric groups was evaluated on Correlation between RRF and SDNN (r = -0.284, p=0.017). Residual renal function was negatively correlated with heart rate variability parameters including SDNN (r = -0.284, p = 0.017), TP (r = -0.247, p = 0.039), and HF (r = -0.238, p = 0.047).
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