Key result
Multiparametric CMR T2 mapping accurately discriminated chronic from healed myocarditis (AUC 0.89) and chronic myocarditis from dilated cardiomyopathy (AUC 0.92, both p<0.0001).
Why the study?
The study was conducted to discriminate biopsy-proven chronic from healed myocarditis and to differentiate them from dilated cardiomyopathy using cardiac magnetic resonance.
Does multiparametric CMR accurately differentiate between biopsy-proven chronic myocarditis, healed myocarditis, and dilated cardiomyopathy?
Observational (n=259)
Does multiparametric CMR accurately differentiate between biopsy-proven chronic myocarditis, healed myocarditis, and dilated cardiomyopathy?
Effect estimate: AUC 0.89 and 0.92
p-value: p=<0.0001
Multiparametric CMR, particularly T2 mapping, provides high diagnostic accuracy for differentiating chronic myocarditis from healed myocarditis and dilated cardiomyopathy.
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May aid noninvasive differentiation of chronic myocarditis; extends imaging data but leaves open prospective validation before practice change.
Krumm et al. (2022) conducted an observational in Biopsy-proven myocarditis and dilated cardiomyopathy (n=259). Multiparametric cardiac magnetic resonance (CMR) vs. Endomyocardial biopsy (reference standard) was evaluated on Discrimination of chronic from healed myocarditis and chronic myocarditis from DCM using T2 mapping (AUC 0.89 and 0.92, p=<0.0001). Multiparametric CMR T2 mapping accurately discriminated chronic from healed myocarditis (AUC 0.89) and chronic myocarditis from dilated cardiomyopathy (AUC 0.92, both p<0.0001).
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