October 14, 2011Metabolic Syndrome and Related DisordersOpen Access

The newly defined consensus criteria for metabolic syndrome strongly predicted all-cause cardiovascular disease in men (HR 2.92) and women (HR 2.08), performing similarly to existing definitions.

Q: What is the clinical evidence from this study?

Study design: Cohort. Population: Metabolic syndrome (n=6770). Intervention: Metabolic syndrome (consensus criteria) vs. Absence of metabolic syndrome. Primary outcome: All-cause cardiovascular disease (CVD) in men (HR 2.92, 95% CI 2.15-3.95, p=<0.0001).

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Why the study?

Does the presence of metabolic syndrome according to various definitions predict cardiovascular disease in a multiethnic U.S. cohort of men and women?

Population

6,770 asymptomatic, self-identified men and women aged 45-84 years, free of cardiovascular disease at…

Comparison

Presence of metabolic syndrome as defined by… vs Absence of metabolic syndrome

Design

Cohort

Follow-up

average 4.1 years

Key result

The newly defined consensus criteria for metabolic syndrome strongly predicted all-cause cardiovascular disease in men (HR 2.92) and women (HR 2.08), performing similarly to existing definitions.

Authors

PHPawan HariPark Nicollet Methodist Hospital KNKamalakar C. NerusuDetroit Medical Center VVVikas VeerannaCardiac Imaging

Discussion

Member takes

Overview

May support CVD risk stratification with consensus criteria in multiethnic U.S. adults; leaves open whether it improves on prior definitions prospectively.

Study Design

Type

Cohort (n=6,770)

Multicenter

Yes

Structured PICO

Does the presence of metabolic syndrome according to various definitions predict cardiovascular disease in a multiethnic U.S. cohort of men and women?

Population

6,770 healthy multiethnic U.S. adults aged 45-84 years, free of cardiovascular disease at baseline, followed for an average of 4.1 years to evaluate the predictive value of various metabolic syndrome definitions.

Exposure

Presence of metabolic syndrome as defined by various criteria (NCEP, AHA, WHO, IDF, EGIR, and consensus criteria)

Comparator

Absence of metabolic syndrome

Outcome

All-cause cardiovascular disease (CVDA), a composite of myocardial infarction, resuscitated cardiac arrest, definite angina, probable angina (if followed by revascularization), stroke, stroke death, coronary heart disease death, other atherosclerotic and cardiovascular death at average 4.1 years follow-upcomposite

Main Result

Hazard Ratio: 2.92 (95% CI 2.15–3.95)

p-value: p=<0.0001

The newly proposed consensus criteria for metabolic syndrome are as effective as existing definitions in predicting cardiovascular events, though significant gender differences exist in the predictive value of individual components.

Limitations

Relatively small number of cardiovascular events resulting in wider confidence intervals for outcomes such as stroke
Small number of events limits the ability to make race-specific recommendations
Relatively short follow-up period of 4.1 years
Evidence of multicollinearity when adjusting for all metabolic syndrome components together in the secondary model

Cite This Study

Hari et al. (2011) conducted a cohort in Metabolic syndrome (n=6,770). Metabolic syndrome (consensus criteria) vs. Absence of metabolic syndrome was evaluated on All-cause cardiovascular disease (CVD) in men (HR 2.92, 95% CI 2.15-3.95, p=<0.0001). The newly defined consensus criteria for metabolic syndrome strongly predicted all-cause cardiovascular disease in men (HR 2.92) and women (HR 2.08), performing similarly to existing definitions.

synapsesocial.com/papers/6a9df1348dd5fc7fdbd6ee5d https://doi.org/10.1089/met.2011.0087

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October 14, 2011Metabolic Syndrome and Related DisordersOpen Access

The newly defined consensus criteria for metabolic syndrome strongly predicted all-cause cardiovascular disease in men (HR 2.92) and women (HR 2.08), performing similarly to existing definitions.

View Full Paper

Ask AI

Bookmark

Why the study?

Does the presence of metabolic syndrome according to various definitions predict cardiovascular disease in a multiethnic U.S. cohort of men and women?

Population

6,770 asymptomatic, self-identified men and women aged 45-84 years, free of cardiovascular disease at…

Comparison

Presence of metabolic syndrome as defined by… vs Absence of metabolic syndrome

Design

Cohort

Follow-up

average 4.1 years

Key result

The newly defined consensus criteria for metabolic syndrome strongly predicted all-cause cardiovascular disease in men (HR 2.92) and women (HR 2.08), performing similarly to existing definitions.

Authors

PHPawan HariPark Nicollet Methodist Hospital KNKamalakar C. NerusuDetroit Medical Center VVVikas VeerannaCardiac Imaging

Discussion

Member takes

Overview

May support CVD risk stratification with consensus criteria in multiethnic U.S. adults; leaves open whether it improves on prior definitions prospectively.

Study Design

Type

Cohort (n=6,770)

Multicenter

Yes

Structured PICO

Does the presence of metabolic syndrome according to various definitions predict cardiovascular disease in a multiethnic U.S. cohort of men and women?

Population

Exposure

Presence of metabolic syndrome as defined by various criteria (NCEP, AHA, WHO, IDF, EGIR, and consensus criteria)

Comparator

Absence of metabolic syndrome

Outcome

Main Result

Hazard Ratio: 2.92 (95% CI 2.15–3.95)

p-value: p=<0.0001

Limitations

Relatively small number of cardiovascular events resulting in wider confidence intervals for outcomes such as stroke
Small number of events limits the ability to make race-specific recommendations
Relatively short follow-up period of 4.1 years
Evidence of multicollinearity when adjusting for all metabolic syndrome components together in the secondary model

Cite This Study

synapsesocial.com/papers/6a9df1348dd5fc7fdbd6ee5d https://doi.org/10.1089/met.2011.0087

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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