Why the study?
Does the presence of metabolic syndrome by different definitions predict cardiovascular events in a population with high prevalence of obesity and diabetes?
Population
3,945 participants from the Strong Heart Study cohort without prevalent cardiovascular disease.
Comparison
Presence of metabolic syndrome assessed by World… vs Absence of metabolic syndrome
Design
Cohort
Follow-up
10-year
Key result
Metabolic syndrome was significantly associated with a higher 10-year incidence of fatal and nonfatal cardiovascular events across all definitions (P<0.0001).
Authors
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May refine CV risk stratification in obese/diabetic cohorts; extends associations across definitions but leaves optimal criteria and management impact open.
Cohort (n=3,945)
Does the presence of metabolic syndrome by different definitions predict cardiovascular events in a population with high prevalence of obesity and diabetes?
p-value: p=<0.0001
Metabolic syndrome is a strong predictor of 10-year cardiovascular events in both diabetic and nondiabetic individuals, with the WHO definition showing the greatest predictive value in diabetic patients.
Simone et al. (2007) conducted a cohort in Metabolic syndrome (n=3,945). Metabolic syndrome vs. Absence of metabolic syndrome was evaluated on 10-year incidence of combined fatal and nonfatal cardiovascular events, including stroke, coronary heart disease, and congestive heart failure (p=<0.0001). Metabolic syndrome was significantly associated with a higher 10-year incidence of fatal and nonfatal cardiovascular events across all definitions (P<0.0001).
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