March 23, 2010Journal of Hypertension
Over 12-year follow-up (179 cardiovascular events, 233 deaths), the risks of fatal and nonfatal cardiovascular events, diabetes mellitus, hypertension, and LVH were similar for the three definitions, although AHA and IDF definitions were more sensitive than ATPIII in identifying metabolic syndrome.
Why the study?
Do different definitions of metabolic syndrome (ATPIII, AHA, IDF) impact the predicted risk of cardiovascular events, death, and organ damage?
Population
2,051 participants with measured office, home and ambulatory blood pressure as well as metabolic…
Comparison
Metabolic syndrome defined by AHA and IDF criteria vs Metabolic syndrome defined by ATPIII criteria
Design
Cohort
Follow-up
12 years
Authors
Discussion
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Member takes
Overview
Similar long-term risks across definitions support interchangeable prognostic use; leaves open impact of sensitivity differences on screening yield.
Structured PICO
Do different definitions of metabolic syndrome (ATPIII, AHA, IDF) impact the predicted risk of cardiovascular events, death, and organ damage?
P
Population
2,051 participants with measured office, home and ambulatory blood pressure as well as metabolic, anthropometric and echocardiographic variables
I
Intervention
Metabolic syndrome defined by AHA (American Heart Association) and IDF (International Diabetes Federation) criteria
C
Comparator
Metabolic syndrome defined by ATPIII (National Cholesterol Education Program Adult Treatment Panel III) criteria
O
Outcome
Long-term risk of cardiovascular events and death for any causecomposite
The AHA and IDF definitions of metabolic syndrome are more sensitive than the ATPIII definition, while all three similarly predict the long-term risk of cardiovascular events, death, and target organ damage.
Cite This Study
Mancia et al. (2010) studied this question.