Key result
Metabolic syndrome was associated with a 5- to 6-fold increased risk of new-onset diabetes (P<0.001), as well as significantly increased risks of new-onset hypertension and left ventricular hypertrophy.
Why the study?
Does metabolic syndrome increase the long-term risk of developing diabetes, hypertension, and left ventricular hypertrophy in a general population?
Population
1412 individuals representative of the general population of Monza
Comparison
Presence of metabolic syndrome at baseline vs Absence of metabolic syndrome at baseline
Design
Cohort
Follow-up
10 years
Authors
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Metabolic syndrome may aid risk stratification in primary care; leaves open whether reversal alters incident diabetes, hypertension, or LVH.
Cohort (n=1,412)
No
Does metabolic syndrome increase the long-term risk of developing diabetes, hypertension, and left ventricular hypertrophy in a general population?
Effect estimate: Adjusted risk 5 to 6 times greater
p-value: p=< 0.001
Metabolic syndrome is associated with a markedly increased 10-year risk of developing diabetes, hypertension, and left ventricular hypertrophy in the general population.
Mancia et al. (2008) conducted a cohort in Metabolic syndrome (n=1,412). Metabolic syndrome vs. Individuals without metabolic syndrome was evaluated on New onset diabetes mellitus (Adjusted risk 5 to 6 times greater, p=< 0.001). Metabolic syndrome was associated with a 5- to 6-fold increased risk of new-onset diabetes (P<0.001), as well as significantly increased risks of new-onset hypertension and left ventricular hypertrophy.
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