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January 1, 2023Timocki medicinski glasnikOpen Access

The effect of the metabolic syndrome on the incidence and degree of left ventricular myocardial hypertrophy in hypertensive patients

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Key result

Metabolic syndrome in hypertensive patients was associated with a significantly higher prevalence of left ventricular hypertrophy (64% vs 36%, p=0.027) compared to hypertension alone.

Why the study?

To determine the impact of metabolic syndrome and obesity on the incidence and degree of severity of left ventricular hypertrophy in hypertensive patients.

Does the presence of metabolic syndrome increase the incidence and severity of left ventricular hypertrophy in hypertensive patients?

Population

55 consecutive hypertensive patients

Comparison

Hypertensive patients with MetS vs hypertensive patients without MetS

Design

Observational cross-sectional study

Authors

IĐIgor ĐorđijoskiMMMaja MladenovićARAnastasija Raščanin

Discussion

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Member takes

Overview

Higher LVH prevalence in hypertensive MetS patients; hypothesis-generating observational link that leaves causal role and practice implications open.

Study Design

Type

Cross-Sectional (n=55)

Multicenter

No

Structured PICO

Does the presence of metabolic syndrome increase the incidence and severity of left ventricular hypertrophy in hypertensive patients?

P
Population
55 hypertensive patients (mean age 53.6 years, 61.8% female), including 22 with metabolic syndrome and 33 without, evaluated cross-sectionally for left ventricular hypertrophy.
E
Exposure
Presence of metabolic syndrome (MetS)
C
Comparator
Hypertensive patients without metabolic syndrome
O
Outcome
Incidence (prevalence) and degree of severity of left ventricular hypertrophy (LVH) measured by left ventricular mass using echocardiographysurrogate

Main Result

Absolute Event Rate: 64% vs 36%

p-value: p=0.027

Metabolic syndrome in hypertensive patients is associated with a significantly higher prevalence and severity of left ventricular hypertrophy, suggesting non-hemodynamic factors play a key role in cardiac remodeling.

Limitations

  • Small sample size
  • Inability to measure parameters of systemic inflammation (hsCRP, interleukins) and insulin resistance (HOMA index, insulinemia during OGTT)
  • Inability to observe parameters of systemic inflammation (hsCRP, interleukins)
  • Inability to measure insulin resistance (HOMA index, OGTT)

Cite This Study

Đorđijoski et al. (2023) conducted a cross-sectional in Hypertension with or without metabolic syndrome (n=55). Metabolic syndrome vs. Hypertension without metabolic syndrome was evaluated on Prevalence of left ventricular hypertrophy (LVH) (p=0.027). Metabolic syndrome in hypertensive patients was associated with a significantly higher prevalence of left ventricular hypertrophy (64% vs 36%, p=0.027) compared to hypertension alone.

synapsesocial.com/papers/6a75b6b5ae41e4ffbd6a3c1ehttps://doi.org/10.5937/tmg2301005q
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Obesity and hypertensive heart disease: focus on body composition and sex differences2016 · 50 citations
  2. 2Hypertension in Metabolic Syndrome: Novel Insights2019 · 101 citations
  3. 3Joint influences of obesity, diabetes, and hypertension on indices of ventricular remodeling: Findings from the community-based Framingham Heart Study2020 · 42 citations
  4. 4Impact of pulse pressure on left ventricular global longitudinal strain in normotensive and newly diagnosed, untreated hypertensive patients2016 · 37 citations
  5. 5Left Ventricular Geometric Patterns in Normotensive Type 2 Diabetic Patients in Nigeria: An Echocardiographic Study2009 · 8 citations