What question did this study set out to answer?

To determine whether metabolic syndrome differentially influences left ventricular mass, geometry, and systolic function in hypertensive men versus women.

April 3, 2006Hypertension

Different Impact of the Metabolic Syndrome on Left Ventricular Structure and Function in Hypertensive Men and Women

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Why the study?

Does metabolic syndrome have a different impact on left ventricular structure and function in untreated hypertensive men versus women?

Population

618 nondiabetic, untreated hypertensive subjects

Comparison

Presence of metabolic syndrome (MS) vs Absence of metabolic syndrome

Design

Cross-sectional

Authors

GSGiuseppe SchillaciUniversity of Pisa MPMatteo PirroGeneral / Preventive / Lipids GPGiacomo PucciVascular Medicine

Discussion

Member takes

Implication

Supports sex differences in MS-LV mass association among hypertensives; hypothesis-generating and requires prospective confirmation before clinical consideration.

Key Points

To determine whether metabolic syndrome differentially influences left ventricular mass, geometry, and systolic function in hypertensive men versus women.
Evaluated 618 nondiabetic, untreated hypertensive subjects using echocardiography to quantify left ventricular mass, relative wall thickness, and midwall fractional shortening.
Performed multivariable regression analyses adjusting for age, body mass index, 24-hour systolic blood pressure, and other hemodynamic and nonhemodynamic confounders.
Women with metabolic syndrome exhibited a 24% greater left ventricular mass (49.5±12 vs 40.0±10 g x m^-2.7; P<0.001) and higher hypertrophy prevalence (37% vs 14%; P<0.001), compared with a 9% increase (50.3±12 vs 46.1±10 g x m^-2.7; P=0.003) and non-significant difference in men (39% vs 29%; P=0.09).
Multivariable adjustment confirmed metabolic syndrome was independently associated with greater left ventricular mass index in women (regression coefficient, 4.80; P<0.001) but not in men.
Women with metabolic syndrome had significantly increased relative wall thickness (0.42±0.07 vs 0.39±0.07; P=0.004) and reduced afterload-corrected midwall fractional shortening (94.0±12% vs 101.0±13%; P<0.001), while no structural or functional differences emerged in men.

Structured PICO

Does metabolic syndrome have a different impact on left ventricular structure and function in untreated hypertensive men versus women?

Population

618 nondiabetic, untreated hypertensive subjects

Intervention

Presence of metabolic syndrome (MS)

Comparator

Absence of metabolic syndrome

Outcome

Left ventricular (LV) mass and function assessed by echocardiographysurrogate

Metabolic syndrome is independently associated with a significantly greater increase in left ventricular mass and depressed function in untreated hypertensive women compared to men.

Cite This Study

Schillaci et al. (2006) studied this question.

synapsesocial.com/papers/6a73b335c973d0bd5a69eddc https://doi.org/10.1161/01.hyp.0000216778.83626.39

Topics

Hypertension management Echocardiography

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Implication

Supports sex differences in MS-LV mass association among hypertensives; hypothesis-generating and requires prospective confirmation before clinical consideration.

Different Impact of the Metabolic Syndrome on Left Ventricular Structure and Function in Hypertensive Men and Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Different Impact of the Metabolic Syndrome on Left Ventricular Structure and Function in Hypertensive Men and Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider