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January 4, 2007European Journal of Clinical Investigation

The IDF definition of metabolic syndrome identified a higher prevalence (25.8% in men, 19.5% in women) than NCEP or WHO definitions, but excess subjects had less insulin resistance and atherosclerosis.

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Why the study?

Does the IDF definition of metabolic syndrome identify subjects with similar insulin resistance and carotid atherosclerosis compared to the NCEP and WHO definitions?

Population

1518 subjects free of clinical atherosclerosis from the Salzburg Atherosclerosis Prevention Program in…

Comparison

Application of the International Diabetes… vs Application of the National Cholesterol…

Design

Cross-sectional

Key result

The IDF definition of metabolic syndrome identified a higher prevalence (25.8% in men, 19.5% in women) than NCEP or WHO definitions, but excess subjects had less insulin resistance and atherosclerosis.

Authors

ASA. SandhoferBIBernhard IglsederBPBernhard Paulweber

Discussion

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Overview

IDF criteria may overidentify lower-risk subjects; leaves open optimal metabolic syndrome definition for insulin resistance and atherosclerosis.

Study Design

Type

Cross-Sectional (n=1,518)

Structured PICO

Does the IDF definition of metabolic syndrome identify subjects with similar insulin resistance and carotid atherosclerosis compared to the NCEP and WHO definitions?

P
Population
1,518 subjects free of clinical atherosclerosis from the SAPHIR program, assessed for metabolic syndrome prevalence and characteristics.
E
Exposure
Application of the International Diabetes Federation (IDF) definition of metabolic syndrome
C
Comparator
Application of the National Cholesterol Education Program (NCEP) and World Health Organization (WHO) definitions of metabolic syndrome
O
Outcome
Frequency, concordance, clinical and laboratory stigmata, and carotid atherosclerosis (intima media thickness and plaque extent)surrogate

The IDF definition of metabolic syndrome identifies more individuals than NCEP or WHO criteria, but these additional subjects have less insulin resistance and carotid atherosclerosis, potentially blurring the distinction between health and disease.

Cite This Study

Sandhofer et al. (2007) conducted a cross-sectional in Metabolic syndrome (n=1,518). IDF definition of metabolic syndrome vs. NCEP and WHO definitions of metabolic syndrome was evaluated on Prevalence of metabolic syndrome. The IDF definition of metabolic syndrome identified a higher prevalence (25.8% in men, 19.5% in women) than NCEP or WHO definitions, but excess subjects had less insulin resistance and atherosclerosis.

synapsesocial.com/papers/6a9df1358dd5fc7fdbd6ee62https://doi.org/10.1111/j.1365-2362.2007.01751.x
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Prevalence of the metabolic syndrome in patients with carotid disease according to NHLBI/AHA and IDF criteria: a cross-sectional study2012 · 19 citations
  2. 2The relation of metabolic syndrome according to five definitions to cardiovascular risk factors - a population-based study2009 · 33 citations
  3. 3Prevalence of the Metabolic Syndrome Defined by the International Diabetes Federation Among Adults in the U.S.2005 · 1,199 citations
  4. 4Comparison of metabolic syndrome prevalence and characteristics using five different definitions in China: a population-based retrospective study2024 · 22 citations
  5. 5COMPARATIVE EVALUATION OF DIAGNOSTIC CRITERIA FOR METABOLIC SYNDROME IN OVERWEIGHT/OBESE ADULT PATIENTS2024