Key result
Preheparin lipoprotein lipase levels were significantly lower in obese Japanese children with metabolic syndrome compared to those without (48.4 vs 60.7 ng/ml, p<0.05).
Cross-Sectional (n=102)
Preheparin LPL levels decrease in obese children with metabolic syndrome, suggesting it may serve as a marker for insulin resistance and metabolic derangement in this population.
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May mark metabolic syndrome in obese children; leaves open prospective validation before any clinical use.
The aim of this study was to clarify the relationship between preheparin lipoprotein lipase (LPL) and derangements of metabolic status in obese Japanese children. We examined 102 obese children (55 boys and 47 girls; mean age 10.9 yr). Anthropometry, blood pressure and levels of liver transaminases, serum lipids and lipoproteins, uric acid, fasting blood glucose (FBG), serum insulin, LPL, leptin and adiponectin were measured. The subjects were divided into the metabolic syndrome (MS) and non-MS groups. The levels of LPL were compared between these groups. Statistical analysis showed that the LPL levels were significantly lower in the MS group compared with the non-MS group, with the levels decreasing progressively as the number of MS components increased. We conclude that LPL levels decrease also in obese Japanese children with a deteriorated metabolic status in the same way as in adults.
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Abe et al. (2011) conducted a cross-sectional in Obesity and Metabolic Syndrome (n=102). Metabolic syndrome vs. Non-metabolic syndrome was evaluated on Preheparin serum lipoprotein lipase (LPL) levels (ng/ml) (p=<0.05). Preheparin lipoprotein lipase levels were significantly lower in obese Japanese children with metabolic syndrome compared to those without (48.4 vs 60.7 ng/ml, p<0.05).
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