Key result
Orthotopic heart transplantation was followed by death most commonly due to right-sided heart failure (15%), infection (13%), and multisystem organ failure (10%) among 39 autopsied patients.
Why the study?
What are the postmortem causes of death and sudden cardiac death in patients following orthotopic heart transplantation?
Population
39 autopsied patients who died following their first orthotopic heart transplantation.
Design
Case_series
Follow-up
up to 16 years (1985-2001)
Authors
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Emphasizes vigilance for right heart failure and infection post-transplant; leaves open optimal prevention in larger prospective cohorts.
Observational (n=39)
No
What are the postmortem causes of death and sudden cardiac death in patients following orthotopic heart transplantation?
Right-sided heart failure and infection are leading causes of overall mortality post-heart transplant, while sudden cardiac arrest is a significant cause of late mortality often driven by graft vascular disease or acute rejection.
Alexander et al. (2003) conducted an observational in Post-cardiac transplantation (n=39). Orthotopic heart transplantation was evaluated on Cause of death. Orthotopic heart transplantation was followed by death most commonly due to right-sided heart failure (15%), infection (13%), and multisystem organ failure (10%) among 39 autopsied patients.
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