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September 6, 2026Journal of the American College of Cardiology74 citations

Predictors and Clinical Impact of Myocardial Injury After Transcatheter Aortic Valve Replacement

Predictors and Impact of Myocardial Injury After Transcatheter Aortic Valve Replacement

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Why the study?

Cardiac biomarker release post-TAVR is common, but its clinical impact across different valve types and procedural approaches remains unknown.

Population

1,131 consecutive patients undergoing TAVR

Comparison

Degree of cardiac biomarker elevation (CK-MB rise) post-TAVR

Design

Multicenter study

Follow-up

Median of 21 months

Key result

A greater rise in CK-MB levels after transcatheter aortic valve replacement was independently associated with increased 30-day, late overall, and cardiovascular mortality (p < 0.001).

Authors

HRHenrique Barbosa RibeiroLNLuis Nombela‐FrancoAMAntonio J. Muñoz-García

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Overview

Observational study demonstrates predictors and outcomes of myocardial injury in aortic stenosis patients, indicating opportunities to reduce periprocedural cardiac risk.

Key Points

  • To identify clinical and procedural predictors of periprocedural myocardial injury and determine its impact on outcomes following transcatheter aortic valve replacement.
  • Evaluated post-procedural elevation of cardiac biomarkers, such as cardiac troponin, following transcatheter aortic valve replacement.
  • Analyzed baseline clinical characteristics, anatomical factors, and procedural variables associated with acute myocardial damage and subsequent mortality.
  • Identified key procedural and anatomical risk factors that independently predict the extent of periprocedural myocardial injury.
  • Demonstrated that substantial myocardial injury following valve replacement significantly correlates with increased risk of post-operative adverse events and reduced survival.

Study Design

Type

Cohort (n=1,131)

Multicenter

Yes

PICO

P
Population
1,131 consecutive patients undergoing transcatheter aortic valve replacement, followed for a median of 21 months.
E
Exposure / Comparator
Myocardial injury (rise in CK-MB levels) vs No or lesser rise in CK-MB levels
O
Primary Outcome
30-day, late overall and cardiovascular mortality, p=<0.001

Main Result

p-value: p=<0.001

Cite This Study

Ribeiro et al. (2015) conducted a cohort in Patients undergoing transcatheter aortic valve replacement (TAVR) (n=1,131). Myocardial injury (rise in CK-MB levels) vs. No or lesser rise in CK-MB levels was evaluated on 30-day, late overall and cardiovascular mortality (p=<0.001). A greater rise in CK-MB levels after transcatheter aortic valve replacement was independently associated with increased 30-day, late overall, and cardiovascular mortality (p < 0.001).

synapsesocial.com/papers/6a9dfa01415d0d2013bfd9c8https://doi.org/10.1016/j.jacc.2015.08.881
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