Key result
Male sex was associated with a significantly larger mean left atrial volume compared to women (59.2 vs 48.54 cm3, P<0.0001), with no differences in tissue Doppler imaging measurements.
Cross-Sectional (n=276)
No
Absolute Event Rate: 59.2% vs 48.54%
p-value: p=< 0.0001
Age affects lateral and mean E/Ea ratios but not septal E/Ea, while sex influences left atrial size but not tissue Doppler imaging measurements of diastolic function.
Sex-specific LA volume references may aid echo interpretation; leaves open impact on diastolic function grading.
BACKGROUND: The effect of age and gender on tissue Doppler imaging measurements comparing the septal and mitral annulus needs to be investigated. METHODS: We investigated in 276 outpatients in a university cardiology practice the relationship of age and gender to left atrial (LA) size, LA volume, mitral pulse-wave Doppler E/A ratio, E/Ea ratios by tissue Doppler image of mitral annular velocity (TDI), and left ventricular diastolic dysfunction (LVDD) by TDI. RESULTS: Mitral E/A inflow was statistically decreased with age. E/Ea ratios of the lateral and mean of both lateral and septal annulus showed a statistical increase with age, while the E/Ea ratio of the septal annulus did not correlate with age. When comparing men and women of all ages, the mean LA volume for men was 59.2 cm3 +/- 24.36 cm3 versus 48.54 cm3 +/- 16.14 cm3 (P-value < 0.0001) and the mean LA size was 4.0 + 0.51 cm for men and 3.65 + 0.47 for women (P-value < 0.0001). There was no statistical difference between men and women when looking at mitral E/A inflow ratio, deceleration time, E/Ea ratio of the septal annulus, E/Ea ratio of the lateral annulus, E/Ea ratio of the mean of both septal and lateral annulus, and grades of LVDD. CONCLUSION: In patients 70 years of age or older, the mean diastolic grade was mild-to-moderate LVDD when using lateral or mean of septal and lateral annular measurements. When only the septal annular measurements were used to determine diastolic grade, all four age groups showed a mean of mildly to moderately impaired LVDD and showed no correlation with age. There were no differences in tissue Doppler imaging measurements between men and women.
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Park et al. (2007) conducted a cross-sectional in Left ventricular diastolic dysfunction (n=276). Male sex vs. Female sex was evaluated on Mean left atrial volume (p=< 0.0001). Male sex was associated with a significantly larger mean left atrial volume compared to women (59.2 vs 48.54 cm3, P<0.0001), with no differences in tissue Doppler imaging measurements.
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