Key result
Cardiac sympathin was found to be partially identical to nor-epinephrine, exerting similar effects on blood pressure, heart rate, and the electrocardiogram.
Early basic science research demonstrating that cardiac 'sympathin' is functionally and chemically similar to nor-epinephrine.
Links cardiac sympathin to nor-epinephrine in animals; leaves open translation to human sympathetic therapies.
In view of the growing recognition of the pathogenic role of the adrenosympathetic humoral neurotransmitters in the heart muscle as chemical anoxia-producing agents, cardiac "sympathin" was extracted and assayed both colorimetrically and biologically, and some of its chemical and pharmacodynamic properties were studied in detail. It proved to be at least in part identical with nor-epinephrine (arterenol) and to exert effects analogous to those of epinephrine and nor-epinephrine upon blood pressure, heart rate and the electrocardiogram (depression or inversion of the T wave). Its action was intensified by cocaine and counteracted by nitroglycerine.
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Raab et al. (1950) studied this question. Cardiac sympathin was evaluated on Chemical and pharmacodynamic properties (blood pressure, heart rate, electrocardiogram). Cardiac sympathin was found to be partially identical to nor-epinephrine, exerting similar effects on blood pressure, heart rate, and the electrocardiogram.
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