Key result
Depletion and refilling of intracellular Ca2+ stores control the amplitude of an electrogenic influx pathway in vascular endothelium, with fluctuations occurring during imbalance.
Population
Vascular endothelium and other nonexcitable cells
Design
Preclinical
Authors
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Hypothesis-generating for endothelial Ca2+ dynamics; extends mechanistic insights but requires human validation before clinical relevance.
The study demonstrates that the depletion and refilling of intracellular Ca2+ stores directly control the amplitude of electrogenic Ca2+ influx in vascular endothelium.
Vaca et al. (1993) studied this question. 2',5',-di(tert-butyl-1,4-benzohydroquinone was evaluated on inward Ca2+ current and depletion of intracellular Ca2+ stores. Depletion and refilling of intracellular Ca2+ stores control the amplitude of an electrogenic influx pathway in vascular endothelium, with fluctuations occurring during imbalance.
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