Key result
Pharmacological inhibition of the plasma membrane Ca2+ pump abolished the secondary decay phase of the capacitative Ca2+ entry transient in vascular endothelial cells.
Population
Vascular endothelial cells
Comparison
Pharmacological inhibition of the plasma… vs Control conditions (uninhibited)
Design
Preclinical
Authors
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No change to clinical care indicated; hypothesis-generating for plasma membrane Ca2+ pump targeting in human vascular research.
The plasma membrane Ca2+ pump plays an important modulatory role in the net cellular gain of Ca2+ during capacitative Ca2+ entry in vascular endothelial cells.
Klishin et al. (1998) studied this question. Pharmacological inhibition of the plasma membrane Ca2+ pump was evaluated on Biphasic changes of intracellular Ca2+ concentration ([Ca2+]i) and rates of Ca2+ entry. Pharmacological inhibition of the plasma membrane Ca2+ pump abolished the secondary decay phase of the capacitative Ca2+ entry transient in vascular endothelial cells.
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