April 1, 2002Journal of Biological ChemistryOpen Access

Capacitative Calcium Entry Contributes to Nuclear Factor of Activated T-cells Nuclear Translocation and Hypertrophy in Cardiomyocytes

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Population

Neonatal rat ventricular myocytes

Comparison

Inhibitors of capacitative calcium entry vs Inhibitors of L-type channels

Design

Preclinical

Authors

DHDacia L. HuntonHoward Hughes Medical Institute PLPamela A. LucchesiThe University of Texas at Tyler YPYi PangGuangdong Pharmaceutical University

Discussion

Member takes

Implication

CCE inhibition may target hypertrophy pathways; animal data leaves open translation to human HF therapy.

Structured PICO

Population

Neonatal rat ventricular myocytes

Intervention

Inhibitors of capacitative calcium entry (store-operated channels)

Comparator

Inhibitors of L-type channels

Outcome

Cytoplasmic Ca(2+) increase, cardiac hypertrophy, atrial natriuretic factor expression, and nuclear factor of activated T-cells (NFAT) nuclear translocationsurrogate

Capacitative calcium entry plays a crucial role in Ca(2+)-mediated cardiac hypertrophy and NFAT nuclear translocation in cardiomyocytes.

Cite This Study

Hunton et al. (2002) studied this question.

synapsesocial.com/papers/6a72bf74f44fa9f079e01d33 https://doi.org/10.1074/jbc.m107167200

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Capacitative Calcium Entry Contributes to Nuclear Factor of Activated T-cells Nuclear Translocation and Hypertrophy in Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Capacitative Calcium Entry Contributes to Nuclear Factor of Activated T-cells Nuclear Translocation and Hypertrophy in Cardiomyocytes

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider