Key result
Serum angiotensin converting enzyme (ACE) activity was significantly elevated in women with pregnancy-induced hypertension (21 ± 4 units) compared to normotensive pregnant controls (13 ± 5 units).
Why the study?
Is serum ACE activity elevated in pregnant women with pregnancy-induced hypertension compared to normotensive pregnant women?
Population
30 pregnant women at 28-40 weeks gestation, including 16 hospitalized with pregnancy-induced hypertension…
Design
Case-control
Authors
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Elevated ACE in pregnancy-induced hypertension supports mechanistic study; leaves open diagnostic or therapeutic utility pending prospective validation.
Cross-Sectional (n=30)
No
Is serum ACE activity elevated in pregnant women with pregnancy-induced hypertension compared to normotensive pregnant women?
Absolute Event Rate: 21% vs 13%
p-value: p=<0.001
Serum ACE activity is significantly elevated in pregnancy-induced hypertension compared to normotensive pregnancy, independent of maternal age and gestational duration.
Lee et al. (1987) conducted a cross-sectional in Pregnancy-induced hypertension (n=30). Pregnancy-induced hypertension vs. Normotensive pregnancy was evaluated on Serum ACE activity (units) (p=<0.001). Serum angiotensin converting enzyme (ACE) activity was significantly elevated in women with pregnancy-induced hypertension (21 ± 4 units) compared to normotensive pregnant controls (13 ± 5 units).
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