Key result
Chlorpromazine and promethazine potentiated the respiratory depressant effect of thiopentone, reducing respiratory amplitude as demonstrated by spirometer tracing.
Design
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Alerts to potential additive respiratory depression with these combinations; leaves open the interaction magnitude in current anaesthetic practice.
Chlorpromazine and promethazine potentiate the respiratory depressant effects of thiopentone, which can be objectively recorded via spirometry.
D. Reckless (1954) studied this question. Chlorpromazine and promethazine was evaluated on Respiratory amplitude and pattern. Chlorpromazine and promethazine potentiated the respiratory depressant effect of thiopentone, reducing respiratory amplitude as demonstrated by spirometer tracing.
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