Key result
Developing depression after a diagnosis of chronic stable angina was associated with a higher risk of death (HR 1.83; 95% CI 1.62-2.07) and admission for myocardial infarction.
Why the study?
Does the development of subsequent depression increase the risk of adverse clinical outcomes in patients with a new diagnosis of stable angina?
Population
22,917 patients in Ontario, Canada, with a new diagnosis of stable angina based on obstructive coronary…
Comparison
Development of subsequent depression vs Patients who did not develop depression
Design
Cohort
Follow-up
mean 1084 days
Authors
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Subsequent depression signals higher mortality and MI risk in stable angina; hypothesis-generating for screening and intervention trials.
Cohort (n=22,917)
Does the development of subsequent depression increase the risk of adverse clinical outcomes in patients with a new diagnosis of stable angina?
Hazard Ratio: 1.83 (95% CI 1.62–2.07)
Subsequent depression is common in patients with newly diagnosed stable angina and is associated with significantly increased risks of all-cause mortality and myocardial infarction.
Szpakowski et al. (2016) conducted a cohort in chronic stable angina (n=22,917). Depression vs. Nondepressed patients was evaluated on Death (HR 1.83, 95% CI 1.62-2.07). Developing depression after a diagnosis of chronic stable angina was associated with a higher risk of death (HR 1.83; 95% CI 1.62-2.07) and admission for myocardial infarction.
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