Key result
Small for gestational age neonates had higher right (0.30 vs 0.268) and left (0.30 vs 0.25) ventricular myocardial performance indices than appropriate for gestational age neonates (p<0.001).
Why the study?
Small for gestational age babies may have an increased risk of adult cardiovascular disease, but comparative data on neonatal cardiac function in term small versus appropriate for gestational age infants are limited.
Does small for gestational age status alter myocardial performance index in term neonates compared to appropriate for gestational age status?
Cross-Sectional (n=200)
Does small for gestational age status alter myocardial performance index in term neonates compared to appropriate for gestational age status?
Small for gestational age neonates exhibit suboptimal cardiac performance as indicated by higher myocardial performance index values compared to appropriate for gestational age neonates.
Answers are grounded in this paper and cite their sources.
Term SGA neonates show early ventricular dysfunction; leaves open whether targeted neonatal screening or follow-up alters adult cardiovascular risk.
BACKGROUND: It is known that small for gestational age (SGA) babies may be at an increased risk of cardiovascular diseases during adulthood. There is paucity of literature regarding comparative cardiac functions of SGA and appropriate for gestational age (AGA) babies in neonatal period. The present study was conceived to compare the cardiac function of term small and appropriate for gestational age (AGA) babies through a relatively novel echocardiographic index in early neonatal period. OBJECTIVES: To compare values of myocardial performance index (MPI) index (MPI = IVCT + IVRT/ET) at 48-72 hours of age among AGA and SGA babies. METHODS: Morphological and anthropometric assessment of serially born term babies was done at time of birth to recruit hundred each of AGA and SGA babies. Tissue Doppler Imaging (TDI) was done between 48-72 hours for each enrolled baby to assess both right and left ventricle MPI in each group. RESULTS: Mean±SD values for right ventricular MPI in AGA and SGA groups were 0.268 + 0.007 and 0.30 + 0.026 respectively (p < 0.001). Mean±SD values for left ventricular MPI in AGA and SGA groups were 0.25 + 0.012 and 0.30 + 0.017 respectively (p < 0.001). There was significant negative correlation between MPI values for either ventricles and the birth weight (spearmen's rho of -0.66) (p < 0.001). Mean±SD values for LVET in AGA and SGA group were 0.304 + 0.026 and 0.266 + 0.032 respectively (p < 0.001). CONCLUSION: MPI had a higher absolute value in the SGA babies as compared to AGA babies. These observations point towards suboptimal cardiac performance among SGA babies as compared to AGA babies on the basis of myocardial performance index.
No takes yet. Share an insight, caveat, or question.
Vats et al. (2021) conducted a cross-sectional in Small for gestational age (n=200). Small for gestational age (SGA) vs. Appropriate for gestational age (AGA) was evaluated on Right ventricular myocardial performance index (MPI) (p=<0.001). Small for gestational age neonates had higher right (0.30 vs 0.268) and left (0.30 vs 0.25) ventricular myocardial performance indices than appropriate for gestational age neonates (p<0.001).
Synapse has enriched 10 related papers. Consider them for comparative context: