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January 1, 2021Thrombosis UpdateOpen Access

Update on extended prophylaxis for venous thromboembolism following surgery for gynaecological cancers

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Key result

Gynaecological cancer surgery carries a high risk of venous thromboembolism, occurring in 6-7% of patients despite standard prophylaxis, highlighting the need for individualized extended prophylaxis.

Why the study?

Gynaecological cancer surgery has evolved with minimally invasive surgery and shorter hospital stays, prompting an evaluation of VTE risk and the role of extended thromboprophylaxis in this era.

Does extended thromboprophylaxis reduce venous thromboembolism in patients undergoing minimally invasive surgery for gynaecological cancers?

Design

Review

Authors

EIElzahra IbrahimSt. James's HospitalLNLucy NorrisTrinity College DublinFSFeras Abu SaadehTrinity College Dublin

Discussion

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Implication

Persistent VTE risk after gynaecological cancer surgery supports extended prophylaxis consideration; leaves optimal regimen and duration open for trials.

Structured PICO

Does extended thromboprophylaxis reduce venous thromboembolism in patients undergoing minimally invasive surgery for gynaecological cancers?

P
Population
Patients undergoing surgery for gynaecological cancers, particularly minimally invasive surgery (MIS)
I
Intervention
Extended thromboprophylaxis (28 days) with low molecular weight heparin (LMWH)
O
Outcome
Venous thromboembolism (VTE)hard clinical

Extended thromboprophylaxis may not be justified for all patients undergoing minimally invasive surgery for gynaecological cancers due to low VTE risk, highlighting the need for individualized risk assessment.

Limitations

  • Data is lacking regarding the use of new oral anticoagulants in gynaecological cancer patients.

Cite This Study

Ibrahim et al. (2021) conducted a review in Gynaecological cancers. Extended thromboprophylaxis was evaluated on Venous thromboembolism. Gynaecological cancer surgery carries a high risk of venous thromboembolism, occurring in 6-7% of patients despite standard prophylaxis, highlighting the need for individualized extended prophylaxis.

synapsesocial.com/papers/6a9e16f68dd5fc7fdbd6f553https://doi.org/10.1016/j.tru.2021.100038
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Also Consider

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  1. 1Cost-effectiveness of deep venous thrombosis prophylaxis in gynecologic oncology surgery2000 · 51 citations
  2. 2Eight-Year Follow-Up of Patients With Permanent Vena Cava Filters in the Prevention of Pulmonary Embolism2005 · 936 citations
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  4. 4Safety and Efficacy of Apixaban vs Enoxaparin for Preventing Postoperative Venous Thromboembolism in Women Undergoing Surgery for Gynecologic Malignant Neoplasm2020 · 140 citations
  5. 5Multivariable Predictors of Postoperative Venous Thromboembolic Events after General and Vascular Surgery: Results from the Patient Safety in Surgery Study2007 · 324 citations