Key result
Experimental infection of pigs with ASFV/NH/P68 isolate elicited strong IgG responses to specific viral proteins, with significantly higher titres in animals developing lesions.
Population
Pigs infected experimentally with the non-pathogenic ASFV/NH/P68 isolate
Comparison
Experimental infection with the non-pathogenic… vs Asymptomatic vs chronically infected animals
Design
Preclinical
Follow-up
longitudinal
Authors
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Antibody responses to ASFV proteins associate with lesions in pigs; hypothesis-generating for immune correlates, needs validation before clinical translation.
Specific antibody responses to ASFV proteins correlate with clinical outcomes in experimentally infected pigs, with A104R antibodies potentially indicating an effective immune response.
Reis et al. (2007) studied African swine fever. Experimental infection with ASFV/NH/P68 isolate vs. Asymptomatic animals was evaluated on Total and Ig isotype antibody responses against 12 viral proteins. Experimental infection of pigs with ASFV/NH/P68 isolate elicited strong IgG responses to specific viral proteins, with significantly higher titres in animals developing lesions.
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