Key result
Higher serum apelin-12 levels were independently associated with the presence of metabolic inflammatory syndrome in elderly Chinese adults (OR 10.381).
Why the study?
Apelin-12 has been proposed as a novel adipocytokine involved in metabolic disorders, but its relationship with metabolic inflammatory syndrome in the elderly remains to be explored.
Is serum apelin-12 associated with metabolic inflammatory syndrome in elderly Chinese subjects?
Cross-Sectional (n=224)
No
Is serum apelin-12 associated with metabolic inflammatory syndrome in elderly Chinese subjects?
Odds Ratio: 10.381 (95% CI 1.842–69.05)
p-value: p=0.007
Serum apelin-12 is independently associated with metabolic inflammatory syndrome in elderly Chinese and may serve as a potential diagnostic biomarker.
Apelin-12 was associated with MIS in elderly Chinese; leaves open its role as a diagnostic biomarker pending prospective studies.
Background: Apelin-12 has been proposed as a novel adipocytokine with vital roles in metabolic disorders. In this study, we aimed to explore the relationship between serum apelin-12 and metabolic inflammatory syndrome (MIS) in the elderly. Methods: The cross-sectional study involved 224 subjects aged over 60. According to their diagnoses of the four components of MIS (type 2 diabetes, non-alcoholic fatty liver disease, atherosclerosis, and obesity/overweight), they were divided into two groups: the control group (0 or 1 component n=63) and the MIS group (≥2 components, n=161). Serum levels of apelin-12, adiponectin and C-reactive protein were measured by ELISA. Results: Serum apelin-12 was significantly higher in the MIS group than in the control group (1.83 ng/mL (1.59-2.07) vs 1.66 ng/mL (1.45-1.92), P=0.001). Partial correlation analysis showed that apelin-12 levels were positively correlated with fasting insulin (ra=0.169), HOMA-IR (ra=0.183), ALT (ra=0.180), AST (ra=0.145) and CRP (ra=0.140, all Pa<0.05) and negatively associated with adiponectin (ra=-0.211) and HDL-C (ra=-0.156) after controlling age, sex and body mass index. Besides, after adjustment for age, sex, fasting blood glucose, diastolic blood pressure and total triglyceride, apelin-12 was still determined as an independent predictor for MIS. Conclusion: Serum apelin-12 can be an independent risk factor predicting metabolic inflammatory syndrome and may serve as a useful potential marker for the diagnosis of MIS in elderly Chinese.
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Wang et al. (2023) conducted a cross-sectional in Metabolic inflammatory syndrome (n=224). Serum apelin-12 vs. Control group (0 or 1 component of metabolic inflammatory syndrome) was evaluated on Presence of metabolic inflammatory syndrome (MIS) (OR 10.381, 95% CI 1.842-69.050, p=0.007). Higher serum apelin-12 levels were independently associated with the presence of metabolic inflammatory syndrome in elderly Chinese adults (OR 10.381).
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