Key result
Serum heparanase levels were positively correlated with CRP and IL-6 levels (P<0.05), suggesting its involvement in the chronic low-grade inflammatory process of metabolic inflammation syndrome.
Case-Control (n=157)
No
p-value: p=<0.05
Higher serum heparanase levels are positively correlated with inflammatory markers CRP and IL-6, suggesting it may serve as a biomarker for the chronic low-grade inflammatory process in metabolic inflammation syndrome.
May support heparanase as biomarker in metabolic inflammation; hypothesis-generating and should not yet change practice.
AIM: Metabolic inflammation syndrome (MIS) can lead to a series of complications, but its exact inflammatory mechanism is still unclear. The aim of this study was to explore the correlation between heparanase (HPA) and MIS, and the close relationship between HPA and other chronic low-grade inflammation index, such as C-reactive protein (CRP) and interleukin-6 (IL-6). METHODS: A total of 105 patients with MIS in the physical examination population of Huashan Hospital affiliated to Fudan University from May to June 2018 were selected as the MIS group, and 52 patients who were relatively healthy during the same period were used as the control group. The basic clinical data of the selected candidates were collected, the levels of serum HPA, CRP and IL-6 were measured by ELISA, and the levels of blood glucose and blood lipids were also detected. RESULTS: , and TG of MIS group were all significantly elevated (all P<0.05), and HDL-C levels were considerably reduced (P<0.05). Correlation analysis showed that there was a noticeably positive correlation between serum HPA level and CRP, IL-6 levels (P<0.05). CONCLUSION: Higher HPA levels might play a certain role in the occurrence and development of MIS. There was a certain close correlation between serum HPA level and CRP and IL-6 levels, and which indicated that HPA was involved in the chronic low-grade inflammatory reaction process of MIS.
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Zhou et al. (2021) conducted a case-control in Metabolic inflammation syndrome (MIS) (n=157). Metabolic inflammation syndrome vs. Relatively healthy controls was evaluated on Serum HPA, CRP, IL-6, blood glucose, and blood lipid levels (p=<0.05). Serum heparanase levels were positively correlated with CRP and IL-6 levels (P<0.05), suggesting its involvement in the chronic low-grade inflammatory process of metabolic inflammation syndrome.
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