Key result
Women with polycystic ovary syndrome had significantly altered serum levels of apelin (220.92 vs 367.05 pg/ml), TGF-β1, and endoglin compared to non-PCOS controls.
Why the study?
Polycystic ovary syndrome is a common cause of infertility, and the study aimed to evaluate levels of apelin, insulin resistance, transforming growth factor beta 1, and endoglin in affected women.
Case-Control (n=90)
No
Absolute Event Rate: 220.92% vs 367.05%
p-value: p=0.00001
In Iraqi women, PCOS is associated with altered levels of TGF-β1, endoglin, and apelin, which correlate with insulin resistance and may contribute to the metabolic and endothelial dysfunctions seen in the syndrome.
Altered TGF-β1 and s-endoglin in PCOS may reflect endothelial-metabolic dysfunction; leaves open causal cardiovascular role in women.
Polycystic ovary syndrome (PCOS) is one of the most common causes of infertility in women of reproductive age. The aim of the study was to determine the level of apelin, insulin resistance (IR), transforming growth factor beta 1 (TGF-β1), and endoglin in women with polycystic ovary syndrome. Fifty PCOS patients and 40 non-PCOS infertile patients were recruited. The fasting serum levels of folliclestimulating hormone (FSH), luteinizing hormone (LH), testosterone (T), prolactin, fasting blood glucose, insulin, and apelin at the early follicular phase were measured. Levels of apelin, LH, LH/FSH, T, and fasting insulin, as well as homeostatic model assessment of IR (HOMA-IR) in PCOS patients, were significantly higher than in the control group. Correlation analysis showed that apelin level was positively correlated with body mass index and HOMA-IR. Apelin levels and TGF-β1 were significantly increased in PCOS patients while show decrease levels of endoglin.
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Ibrahim et al. (2020) conducted a case-control in Polycystic Ovary Syndrome (n=90). Polycystic Ovary Syndrome vs. Non-PCOS overweight and obese women was evaluated on Serum apelin level (pg/ml) (p=0.00001). Women with polycystic ovary syndrome had significantly altered serum levels of apelin (220.92 vs 367.05 pg/ml), TGF-β1, and endoglin compared to non-PCOS controls.
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