Key result
PCOS is linked to elevated serum vaspin and apelin levels regardless of obesity.
Why the study?
Are serum vaspin and apelin levels altered in Iraqi women with PCOS compared to healthy controls, and how do they relate to obesity?
Case-Control (n=138)
No
Are serum vaspin and apelin levels altered in Iraqi women with PCOS compared to healthy controls, and how do they relate to obesity?
Absolute Event Rate: 2.5% vs 1.5%
p-value: p=0.012
Serum vaspin and apelin levels are elevated in women with PCOS, particularly those who are obese, suggesting a potential role in the pathogenesis of the condition.
The present study aimed to measure serum vaspin and apelin levels in women with PCOS to show their rule in the pathogenesis of PCOS. Ninety eight women with PCOS, 51 non-obese [body mass index (BMI) less than 25 kg/m2] and 47 obese (BMI >25 kg/m2) were enrolled in the study. Each group is compared to apparently healthy women as a control group matched for age and BMI. Clinical history, anthropometric measurements and biochemical and hormonal analysis were determined. The mean serum level of vaspin and apelin showed statistically significant difference between PCOS patients (non-obese and obese) compared to control women (non-obese and obese) respectively. Also, the levels of both parameters (vaspin, apelin)showed significant differences between PCOS obese patients and non-obese ones. It is concluded that serum vaspin and apelin level increased in PCOS women particularly the obese. These data suggest their involvement in the pathogenesis of PCOS
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Waheed et al. (2013) conducted a case-control in Polycystic ovarian syndrome (PCOS) (n=138). Polycystic ovarian syndrome (PCOS) vs. Healthy women matched for age and BMI was evaluated on Serum vaspin levels in obese PCOS patients compared to obese controls (ng/ml) (p=0.012). Serum vaspin and apelin levels were significantly increased in both obese and non-obese women with polycystic ovarian syndrome compared to healthy controls.
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