Key result
Lower body negative pressure at 5.3 kPa caused systolic blood pressure falls greater than 2.7 kPa in a subset of diabetic patients despite intact forearm vasoconstriction.
Why the study?
Does lower body negative pressure reveal differences in cardiovascular and vasomotor responses between diabetic and non-diabetic subjects?
Population
Non-diabetic and diabetic subjects
Comparison
Lower body negative pressure at 1.3, 2.7, and… vs Non-diabetic subjects
Design
Cross-sectional
Authors
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May signal undetected vasomotor impairment in diabetics; hypothesis-generating and requires prospective validation before clinical adoption.
Observational
Does lower body negative pressure reveal differences in cardiovascular and vasomotor responses between diabetic and non-diabetic subjects?
Stepped increases in lower body negative pressure can reliably test the integrity of vasomotor reflexes, revealing localized vasomotor dysfunction in some diabetic patients.
Bennett et al. (1979) conducted an observational in Diabetes mellitus. Lower body negative pressure vs. Non-diabetic subjects was evaluated on Cardiovascular responses including systolic blood pressure and forearm vasoconstriction. Lower body negative pressure at 5.3 kPa caused systolic blood pressure falls greater than 2.7 kPa in a subset of diabetic patients despite intact forearm vasoconstriction.
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