November 1, 1999Journal of Internal Medicine

Reduced transcapillary fluid absorption from skeletal muscle and skin during hypovolaemia in insulin‐dependent diabetes mellitus

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Why the study?

Is transcapillary fluid absorption during hypovolaemic circulatory stress impaired in patients with type 1 diabetes compared to healthy controls?

Population

24 males, comprising 12 with type 1 diabetes with no clinical microangiopathy and 12 healthy controls.

Comparison

Lower body negative pressure to induce… vs Healthy controls undergoing the same LBNP…

Design

Case-control

Authors

HOHenrik OlsenLund University UHU. Lennart HulthénLund University TLToste LänneVascular / Pulmonary Vascular

Discussion

Member takes

Implication

Impaired transcapillary fluid absorption may signal early volume dysregulation in type 1 diabetes; hypothesis-generating case-control observation requiring prospective confirmation.

Structured PICO

Is transcapillary fluid absorption during hypovolaemic circulatory stress impaired in patients with type 1 diabetes compared to healthy controls?

Population

24 males, comprising 12 with type 1 diabetes (age 25 +/- 3 years, duration 8 +/- 1 years) with no clinical microangiopathy and 12 healthy controls (age 22 +/- 2 years).

Intervention

Lower body negative pressure (LBNP: 15, 30 and 60 cmH2O) to induce hypovolaemic circulatory stress.

Comparator

Healthy controls undergoing the same LBNP protocol.

Outcome

Transcapillary fluid absorption from tissue to blood in the upper arm.surrogate

Type 1 diabetes patients exhibit impaired transcapillary fluid absorption during hypovolaemic stress before clinical microangiopathy develops, indicating early defects in plasma volume regulation.

Cite This Study

Olsen et al. (1999) studied this question.

synapsesocial.com/papers/6a84f86ab833edce7a9ea59d https://doi.org/10.1046/j.1365-2796.1999.00511.x

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Implication

Impaired transcapillary fluid absorption may signal early volume dysregulation in type 1 diabetes; hypothesis-generating case-control observation requiring prospective confirmation.

Reduced transcapillary fluid absorption from skeletal muscle and skin during hypovolaemia in insulin‐dependent diabetes mellitus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Reduced transcapillary fluid absorption from skeletal muscle and skin during hypovolaemia in insulin‐dependent diabetes mellitus

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider