Key result
Angiotensin-converting enzyme activity was threefold greater in isolated cerebral microvessels from rabbit brain than rat brain and was tightly associated with endothelial cells.
Authors
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Species differences in cerebral microvascular ACE activity caution against extrapolating rodent data; leaves open endothelial RAS regulation in human cerebrovascular models.
Brecher et al. (1981) studied this question. Rabbit brain cerebral microvessels vs. Rat brain cerebral microvessels and aortic tissue was evaluated on Angiotensin-converting enzyme (ACE) activity. Angiotensin-converting enzyme activity was threefold greater in isolated cerebral microvessels from rabbit brain than rat brain and was tightly associated with endothelial cells.
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