Key result
Inoculation of newborn BALB/c mice with a rhabdomyosarcoma virus isolate resulted in rapid tumor growth primarily from adjacent muscle tissue, demonstrating the virus's affinity to muscle tissue.
This preclinical study demonstrates the strong affinity of a rhabdomyosarcoma virus isolate for muscle tissue in newborn mice, regardless of the inoculation route.
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Hypothesis-generating for viral muscle tropism in rhabdomyosarcoma models; leaves open human relevance pending further validation.
Perk et al. (1967) studied Rhabdomyosarcoma virus infection (n=300). Rhabdomyosarcoma virus isolate was evaluated on Tumor development and pathogenesis. Inoculation of newborn BALB/c mice with a rhabdomyosarcoma virus isolate resulted in rapid tumor growth primarily from adjacent muscle tissue, demonstrating the virus's affinity to muscle tissue.
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