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August 9, 2023Journal of Clinical MedicineOpen Access

Surgery for Infective Endocarditis after Primary Transcatheter Aortic-Valve Replacement—A Retrospective Single-Center Analysis

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Key result

Surgery for infective endocarditis after TAVR in 10 high-risk patients resulted in 1 in-hospital death, with all 9 discharged patients surviving during a mean follow-up of 9 months.

Why the study?

Increasing use of TAVR has expanded the population with aortic-valve prostheses, leading to a rising incidence of prosthetic-valve endocarditis.

Is surgical therapy feasible and safe for patients developing infective endocarditis after TAVR?

Population

10 patients undergoing surgery for prosthetic-valve endocarditis after TAVR

Design

Retrospective single-center analysis

Follow-up

Mean 9 ± 8 month

Authors

RRRomina RöschHeidelberg UniversityLBL. BrendelHeidelberg UniversityKBK. BuschmannJohannes Gutenberg University Mainz

Discussion

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Implication

May support surgery in select high-risk post-TAVR IE cases; hypothesis-generating and requires larger prospective validation.

Study Design

Type

Observational (n=10)

Multicenter

No

Structured PICO

Is surgical therapy feasible and safe for patients developing infective endocarditis after TAVR?

P
Population
10 patients (mean age 79 years) who underwent surgery for prosthetic-valve endocarditis after TAVR, followed for a mean of 9 months.
E
Exposure
Surgical replacement of the infected aortic prosthesis
O
Outcome
In-hospital mortality and post-discharge survivalhard clinical

Surgical therapy for infective endocarditis after TAVR is feasible and yields good survival outcomes despite the high baseline surgical risk of these patients.

Limitations

  • Retrospective design
  • Single-center analysis
  • Small sample size

Cite This Study

Rösch et al. (2023) conducted an observational in Prosthetic-valve endocarditis after TAVR (n=10). Surgery for prosthetic-valve endocarditis was evaluated on In-hospital mortality. Surgery for infective endocarditis after TAVR in 10 high-risk patients resulted in 1 in-hospital death, with all 9 discharged patients surviving during a mean follow-up of 9 months.

synapsesocial.com/papers/6a9e46560bfbee156fd6f37ehttps://doi.org/10.3390/jcm12165177
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transapical aortic valve prosthetic endocarditis2010 · 34 citations
  2. 2Early Surgery versus Conventional Treatment for Infective Endocarditis2012 · 923 citations
  3. 3Updated standardized endpoint definitions for transcatheter aortic valve implantation: the Valve Academic Research Consortium-2 consensus document†2012 · 1,055 citations
  4. 4Diagnosis and Management of Infective Endocarditis and Its Complications1998 · 758 citations
  5. 5Infective Endocarditis in the Transcatheter Aortic Valve Replacement Era: Comprehensive Review of a Rare Complication2012 · 48 citations