Population
Isolated ductal strips from near-term fetal lamb
Comparison
Bradykinin, L-arginine, N omega-nitro-L-arginine… vs Endothelium-denuded preparations and untreated…
Design
Preclinical
Authors
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No immediate change to neonatal PDA care; leaves open bradykinin-NO contributions to human ductal patency.
Demonstrates the presence of a nitric oxide-based relaxing mechanism in the fetal lamb ductus arteriosus, which may contribute to its patency.
Coceani et al. (1994) studied this question.
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